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Test: Apolipoprotein E
Alternate names: ApoE
Description: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents.
Clinical: Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
Methodology: Point mutation analysis
Turn around time: 4 weeks
Transit stability:
Sample: Blood EDTA 5 ml
Type: Genetics
Method: Point mutation analysis
Consultant/scientist: Ms Surita Meldau
Tel: 021 404 4449
email: surita.meldau@nhls.ac.za
Contact for results: Ms Surita Meldau
Tel: 021 404 4449
email: surita.meldau@uct.ac.za
Delivery address C17 NHLS Labs, NGSH, Observatory, 7925
for samples: Cape Town